Biogenesis and quality control of the mitochondrial outer membrane

Doron Rapaport

DoronRapaport23-11-2012-09 crop1
  • PhD work 1992-1995 at the Weizmann Institute of Science, Rehovot
  • Postdoctoral training 1996-2001 at the University of Munich
  • Group leader 2002-2006 at the University of Munich
  • Professor of Biochemistry at the Interfaculty Institute of Biochemistry, University of Tuebingen since 2006

Research Interest

The mitochondrial outer membrane contains a diverse set of proteins including enzymes, pore-forming proteins, regulators of programmed cell death, and those that control the morphology of the organelle.

We investigate the molecular mechanisms by which the various mitochondrial outer membrane proteins are targeted to mitochondria, inserted into the outer membrane and assembled into functional complexes. In addition we aim to understand how proteins that are mistargeted to mitochondria are recognized as such and subsequently removed. We further study the exchange of lipids between mitochondria and other cellular compartments and lipid trafficking within mitochondria. For our studies we use both yeast and mammalian tissue cultures as experimental systems and employ a variety of biochemical, molecular cell biology and genetics assays.

  • overview import 4
    click to enlarge

Import pathways of mitochondrial proteins

Available PhD Projects

No PhD projects offered in the 2021 selection.

Selected Reading

1) Jores, T., A. Klinger, L. Groß, S. Kawano, N. Flinner, et al. (2016) Characterization of the targeting signal in mitochondrial β-barrel proteins. Nature Comm. 7, 12036.

2) Jores, T., J. Lawatscheck, V. Beke, M. Franz-Wachtel, K. Yunoki, et al. (2018) Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteins. J. Cell Biol., 217, 3091-3108. doi: 10.1083/jcb.201712029.

3) Dimmer, K.S., and D. Rapaport (2017) Mitochondrial contact sites as platforms for phospholipid exchange. Biochim. Biophys. Acta 1862, 69-80.